The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

A wide variety of agents activate AMPK, but in many cases the mechanisms remain unclear.
We generated isogenic cell lines stably expressing AMPK complexes containing AMP …

The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status
that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP …

Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal
signals across multiple neuronal cell types. Here, we combine cell-type-specific …

The AMP-activated protein kinase (AMPK) system is a key player in regulating energy
balance at both the cellular and whole-body levels, placing it at centre stage in studies of …

The LKB1→ AMPK cascade is switched on by metabolic stresses that either inhibit ATP
production (eg hypoxia, hypoglycaemia) or that accelerate ATP consumption (eg muscle …

All living organisms depend on dynamic mechanisms that repeatedly reassess the status of
amassed energy, in order to adapt energy supply to demand. The AMP-activated protein …

Although metabolic conditions associated with an increased AMP/ATP ratio are primary
factors in the activation of 5′-adenosine monophosphate-activated protein kinase (AMPK) …