Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
Studies into the mechanisms in resolution of self-limited inflammation and acute reperfusion
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …
injury have uncovered a new genus of pro-resolving lipid mediators coined specialized pro …
Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome
Acute inflammatory responses are protective, yet without timely resolution can lead to
chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self …
chronic inflammation and organ fibrosis. A systems approach to investigate self-limited (self …
Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity
Proinflammatory eicosanoids (prostaglandins and leukotrienes) and specialized pro-
resolving mediators (SPM) are temporally regulated during infections. Here we show that …
resolving mediators (SPM) are temporally regulated during infections. Here we show that …
Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors
The acute inflammatory response is host-protective to contain foreign invaders. Many of
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …
today's pharmacopeia that block pro-inflammatory chemical mediators can cause serious …
[HTML][HTML] Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases
Inflammation is associated with the development of diseases characterized by altered
nutrient metabolism. Although an acute inflammatory response is host-protective and …
nutrient metabolism. Although an acute inflammatory response is host-protective and …
New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration
While protective, the acute inflammatory response when uncontrolled can lead to further
tissue damage and chronic inflammation that is now widely recognized to play important …
tissue damage and chronic inflammation that is now widely recognized to play important …
[HTML][HTML] Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases
Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are
found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with …
found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with …
E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing …
The COVID-19 pandemic has raised international awareness of the importance of rigorous
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …
scientific evidence and the havoc caused by uncontrolled excessive inflammation. Here we …
Human milk and allergic diseases: an unsolved puzzle
There is conflicting evidence on the protective role of breastfeeding in relation to the
development of allergic sensitisation and allergic disease. Studies vary in methodology and …
development of allergic sensitisation and allergic disease. Studies vary in methodology and …