A natural products solution to diabetic nephropathy therapy

Q Hu, L Jiang, Q Yan, J Zeng, X Ma, Y Zhao - Pharmacology & Therapeutics, 2023 - Elsevier
Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …

[HTML][HTML] New progress in drugs treatment of diabetic kidney disease

J Wang, H Xiang, Y Lu, T Wu, G Ji - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Diabetic kidney disease (DKD) is not only one of the main complications of diabetes, but
also the leading cause of the end-stage renal disease (ESRD). The occurrence and …

Protective effect of isoliquiritigenin on experimental diabetic nephropathy in rats: Impact on Sirt-1/NFκB balance and NLRP3 expression

S Alzahrani, SA Zaitone, E Said, M El-Sherbiny… - International …, 2020 - Elsevier
The prevalence of diabetes mellitus (DM) drastically increases worldwide. Persistent
hyperglycemia affects body microvasculature causing injuries to kidney producing diabetic …

Sildenafil and tadalafil reduce the risk of contrast-induced nephropathy by modulating the oxidant/antioxidant balance in a murine model

AM Iordache, AO Docea, AM Buga, O Zlatian… - Food and Chemical …, 2020 - Elsevier
The aim of the study was to evaluate the potential protective role of sildenafil and tadalafil in
contrast-induced nephropathy (CIN) by modulating oxidative stress. Thirty Wistar male rats …

Current concepts on the reno-protective effects of phosphodiesterase 5 inhibitors in acute kidney injury: systematic search and review

G Georgiadis, IE Zisis, AO Docea, K Tsarouhas… - Journal of clinical …, 2020 - mdpi.com
Acute kidney injury (AKI) is associated with increased morbidity, prolonged hospitalization,
and mortality, especially in high risk patients. Phosphodiesterase 5 inhibitors (PDE5Is) …

Monitoring physiological processes of fast-growing broilers during the whole life cycle: Changes of redox-homeostasis effected to trassulfuration pathway predicting …

G Pesti-Asbóth, E Szilágyi, P Bíróné Molnár, J Oláh… - Plos one, 2023 - journals.plos.org
In the broiler industry, the average daily gain and feed conversion ratio are extremely
favorable, but the birds are beginning to approach the maximum of their genetic capacity …

The efficacy of PDE5 inhibitors in diabetic patients

A Swiecicka - Andrology, 2023 - Wiley Online Library
Background Phosphodiesterase 5 inhibitors (PDE5i), since their introduction in the late
1990s, have proven their efficacy in treating several conditions, predominantly pulmonary …

Cyclic nucleotide phosphodiesterase inhibition as a potential therapeutic target in renal ischemia reperfusion injury

K Thapa, TG Singh, A Kaur - Life sciences, 2021 - Elsevier
Abstract Aims Ischemia/reperfusion (I/R) occurs in renal artery stenosis, partial nephrectomy
and most commonly during kidney transplantation. It brings serious consequences such as …

Exploring the Multifaceted Potential of Sildenafil in Medicine

C Pușcașu, A Zanfirescu, S Negreș, OC Șeremet - Medicina, 2023 - mdpi.com
Phosphodiesterase type 5 (PDE5) is pivotal in cellular signalling, regulating cyclic
guanosine monophosphate (cGMP) levels crucial for smooth muscle relaxation and …

Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice

M Harloff, S Prueschenk, R Seifert… - British journal of …, 2022 - Wiley Online Library
Background and Purpose Diabetic nephropathy is the leading cause for end‐stage renal
disease worldwide. Until now, there is no specific therapy available. Standard treatment with …