Advances in pathogenesis and therapeutic strategies for osteoporosis

S Song, Y Guo, Y Yang, D Fu - Pharmacology & therapeutics, 2022 - Elsevier
Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

[HTML][HTML] The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism

J Zhang, W Hu, Z Zou, Y Li, F Kang, J Li, S Dong - Genes & Diseases, 2024 - Elsevier
In recent years, researchers have become focused on the relationship between lipids and
bone metabolism balance. Moreover, many diseases related to lipid metabolism disorders …

Curculigo orchioides polysaccharide COP70-1 stimulates osteogenic differentiation of MC3T3-E1 cells by activating the BMP and Wnt signaling pathways

J Wang, J Yang, Z Tang, Y Yu, H Chen, Q Yu… - International Journal of …, 2023 - Elsevier
The crude polysaccharide CO70 isolated from Curculigo orchioides could alleviate
ovariectomy-induced osteoporosis in rats. To clarify the bioactive components, a new …

The role and applications of extracellular vesicles in osteoporosis

F Fang, J Yang, J Wang, T Li, E Wang, D Zhang, X Liu… - Bone research, 2024 - nature.com
Osteoporosis is a widely observed condition characterized by the systemic deterioration of
bone mass and microarchitecture, which increases patient susceptibility to fragile fractures …

Interaction between ferroptosis and TNF‐α: impact in obesity‐related osteoporosis

X Chen, C Liu, R Yu, Z Gan, Z Zhang… - The FASEB …, 2023 - Wiley Online Library
The relationship of obesity and osteoporosis has been widely studied over the past years.
However, the implications of obesity for bone health remain controversial, and the …

Brain-derived neurotrophic factor promotes orthodontic tooth movement by alleviating periodontal ligament stem cell senescence

L Meng, P Yang, W Zhang, X Zhang, X Rong, H Liu… - Cellular …, 2023 - Elsevier
Orthodontic treatment in older adults is more difficult than in younger adults, partially due to
delayed osteogenesis caused by senescence of human periodontal ligament stem cells …

[HTML][HTML] Niloticin inhibits osteoclastogenesis by blocking RANKL–RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways

H Xu, Y Jia, J Li, X Huang, L Jiang, T Xiang… - Biomedicine & …, 2022 - Elsevier
Dysregulation of osteoclasts or excessive osteoclastogenesis significantly–contributes to the
occurrence and development of osteolytic diseases, including osteoporosis, inflammatory …

[HTML][HTML] Osteoclast-derived exosomes influence osteoblast differentiation in osteoporosis progression via the lncRNA AW011738/miR-24-2-5p/TREM1 axis

J Liu, B Wang, H Chen, X Yu, X Cao… - Biomedicine & …, 2024 - Elsevier
Aims To investigate the molecular mechanism of osteoclast-derived exosomes in
osteoporosis. Main methods RANKL induced osteoclast model was screened for …

Study on the treatment of postmenopausal osteoporosis with quercetin in Liuwei Dihuang Pill based on network pharmacology

F Zhu, W Li, L Wang, B Dai, Z Liu, H Wu… - Journal of Orthopaedic …, 2023 - Springer
Abstract Background Liuwei Dihuang Pill (LP) was verified to alleviate postmenopausal
osteoporosis (PMOP) development. Nevertheless, the major constituent of LP and the …

Esketamine improves cognitive function in sepsis-associated encephalopathy by inhibiting microglia-mediated neuroinflammation

H Li, W Hu, Z Wu, B Tian, Y Ren, X Zou - European Journal of …, 2024 - Elsevier
Microglia-mediated neuroinflammation is critical in the pathogenesis of sepsis-associated
encephalopathy (SAE). Identifying the key factors that inhibit microglia-mediated …