Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

Steroids are important biodynamic agents. Their affinities for various nuclear receptors have
been an interesting feature to utilize them for drug development particularly for receptor …

Abstract (25R)-spirost-5-en-3β-ol, also known as diosgenin (DSG), exerts antiproliferative
activity on diverse cell lines, induces apoptosis, and acts as a chemopreventative agent …

Diosgenin has been modified to furostane derivatives after opening the F-spiroacetal ring.
The aldehyde group at C26 in derivative 8 was unexpectedly transformed to the ketone 9 …

Diverse steroidal compounds have shown antiproliferative activity on certain tumor cell lines;
however, their complete role on cancer cells has not been extensively established since the …

A novel radical‐based approach for the iron‐catalyzed selective cleavage of acetal‐derived
alkylsilyl peroxides, followed by the formation of a carbon–carbon bond is reported. The …

Using various chromatographic separations, seventeen steroids including seven new
compounds, verrucorosteroids A–F (1–6) and verrucorosterone (7), were isolated from the …

Saponins are a structurally diverse class of natural glycosides that possess a broad
spectrum of biological activities. They are composed of hydrophilic carbohydrate moiety and …

Steroidal saponins are natural glycosidic compounds of amphiphilic character. Their diverse
biological activities are directly related to the variability of their structural constitutive …

The synthesis of glucosamine derivatives of the steroidal sapogenins diosgenin and
hecogenin using the N-phthaloyl protected trichloroacetimidate of d-glucosamine as donor …