Recent advances in histone glycation: emerging role in diabetes and cancer
Ever increasing information on genome and proteome has offered fascinating details and
new opportunities to understand the molecular biology. It is now known that histone proteins …
new opportunities to understand the molecular biology. It is now known that histone proteins …
Glycation derived AuNPs bioconjugated novel herbal drug isoferulic acid: As a potential anti-glycation, anti-diabetic and antineoplastic agent
Based on the significance and impact of serum protein glycation and the possibility that
AGEs play a role in diabetes-related complications and cancer, this study examined the anti …
AGEs play a role in diabetes-related complications and cancer, this study examined the anti …
Hydroxyl radical induced structural perturbations make insulin highly immunogenic and generate an auto-immune response in type 2 diabetes mellitus
Reactive oxygen species (ROS) cause oxidative damage to proteins and generate
deleterious by-products which induce a breakdown of immune tolerance and produce …
deleterious by-products which induce a breakdown of immune tolerance and produce …
Glycated LDL generates reactive species that damage cell components, oxidize hemoglobin and alter surface morphology in human erythrocytes
Low-density lipoprotein (LDL) transports cholesterol to various tissues via the blood.
Glycation of LDL occurs during hyperglycemic condition which is characterised by …
Glycation of LDL occurs during hyperglycemic condition which is characterised by …
Methylglyoxal-induces multiple stable changes in human serum albumin before forming nephrotoxic advanced glycation end-products: Injury demonstration in human …
A Gupta, M Khursheed, Z Arif, A Badar… - International Journal of …, 2022 - Elsevier
The minor fraction of methylglyoxal that is not metabolized in healthy humans reacts with
macromolecules to form AGEs. In diabetics, the formation of MG is accelerated; its level may …
macromolecules to form AGEs. In diabetics, the formation of MG is accelerated; its level may …
Elucidating the effect of levothyroxine and triiodothyronine on methylglyoxal derived stress
Purpose Methylglyoxal (MG) is the most potent precursor during the formation of the
advanced glycation end products (AGEs). MG-dependent glycative stress contributes to …
advanced glycation end products (AGEs). MG-dependent glycative stress contributes to …
Biophysical changes in methylglyoxal modified fibrinogen and its role in the immunopathology of type 2 diabetes mellitus
Methylglyoxal (MG), a highly reactive dicarbonyl metabolite gets generated during glucose
oxidation and lipid peroxidation, which contributes to glycation. In type 2 diabetes mellitus …
oxidation and lipid peroxidation, which contributes to glycation. In type 2 diabetes mellitus …
Characterization of glyoxal modified LDL: Role in the generation of circulating autoantibodies in type 2 diabetes mellitus and coronary artery disease
Aims: This study aims to investigate the role of glyoxal modified LDL in the
immunopathology of diabetes and cardiovascular disease. Background: Glycoxidation of …
immunopathology of diabetes and cardiovascular disease. Background: Glycoxidation of …
On the irrationality of rational design of an HIV vaccine in light of protein intrinsic disorder
VN Uversky - Archives of Virology, 2021 - Springer
The lack of progress in finding an efficient vaccine for a human immunodeficiency virus (HIV)
is daunting. In fact, this search has spanned nearly four decades without much success …
is daunting. In fact, this search has spanned nearly four decades without much success …