Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …

The identification of T-cell epitopes is key for a complete molecular understanding of
immune recognition mechanisms in infectious diseases, autoimmunity and cancer. T-cell …

T cell bispecific antibodies (TCBs) are the focus of intense development for cancer
immunotherapy. Recently, peptide-MHC (major histocompatibility complex)-targeted TCBs …

T cell receptor (TCR)–based immunotherapy has emerged as a promising therapeutic
approach for the treatment of patients with solid cancers. Identifying peptide–human …

Abstract The SysteMHC Atlas v1. 0 was the first public repository dedicated to mass
spectrometry-based immunopeptidomics. Here we introduce a newly released version of the …

The identification of tumor-specific antigens (TSAs) is critical for developing effective cancer
immunotherapies. Mass spectrometry (MS)-based immunopeptidomics has emerged as a …

The immunopeptidome is the repertoire of peptides bound and presented by the MHC class
I, class II, and non-classical molecules. The peptides are produced by the degradation of …

Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell
immunity against current and emerging SARS-CoV-2 variants. Precise identification of …

Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma—namely
MEK/BRAF kinase inhibitors, immune checkpoint inhibitors (ICIs), and targeted …

Transposable elements (TEs) are repetitive sequences representing~ 45% of the human
and mouse genomes and are highly expressed by medullary thymic epithelial cells …