TRPV5 is one of the two channels in the TRPV family that exhibit high selectivity to Ca 2+
ions. TRPV5 mediates Ca 2+ influx into cells as the first step to transport Ca 2+ across …

Kidneys critically contribute to the maintenance of whole-body homeostasis by governing
water and electrolyte balance, controlling extracellular fluid volume, plasma osmolality, and …

Objective: Experiments were carried out to investigate whether diuretics
(hydrochlorothiazide+ furosemide) impact on the effects of a sodium-dependent glucose …

The most common metabolic abnormality found in calcium (Ca) kidney stone formers is
idiopathic hypercalciuria (IH). Using endogenous lithium (Li) clearance, we previously …

Background Carbonic anhydrase inhibitors (CAI) are mild diuretics, hence not widely used
in fluid overloaded states. They are however the treatment of choice for certain non-kidney …

Kidney stones are concretions of different mineral salts mixed with an organic matrix that
form in the upper urinary tract. As a stone moves from the kidney to the ureter, it can present …

Lithium is the most common cause of nephrogenic diabetes insipidus (Li-NDI).
Hydrochlorothiazide (HCTZ) combined with amiloride is the mainstay treatment in Li-NDI …

TRPV5 and TRPV6 are unique members of the TRP super family. They are highly selective
for Ca 2+ ions with multiple layers of Ca 2+-dependent inactivation mechanisms, expressed …

Aim: To evaluate the therapeutic effect of hydrochlorothiazide in idiopathic renal
hypercalciuria. Methods: We retrospectively analysed the data of 28 children (6.0±4.1 years …

The versatility of the intrarenal immunologic micromilieu through dietary modification and the
subsequent effects on susceptibility to ischemic acute kidney injury (AKI) are unclear. We …