The natural microenvironment of tumors is composed of extracellular matrix (ECM), blood
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …

The pre-metastatic niche—the accumulation of aberrant immune cells and extracellular-
matrix proteins in target organs—primes the initially healthy organ microenvironment and …

Introduction: Drug toxicity often goes undetected until clinical trials, which are the most costly
and dangerous phase of drug development. Both the cultures of human cells and animal …

Biomimetic polymers and materials have been widely used in tissue engineering for
regeneration and replication of diverse types of both normal and diseased tissues. Cancer …

The majority of in vitro studies assessing cancer treatments are performed in two-
dimensional (2D) monolayers and are subsequently validated in in vivo animal models …

Study Design. Literature review. Objective. To evaluate the association between
recombinant human bone morphogenetic protein-2 (rhBMP-2) and malignancy. Summary of …

Biological models are necessary tools for gaining insight into underlying mechanisms
governing complex pathologies such as cancer in the bone. Models range from in vitro …

Metastatic prostate cancer spreads preferentially to the bone, causing skeletal complications
associated with significant morbidity and a poor prognosis, despite current therapeutic …

While the skeleton is not the only organ where metastasis can occur, it is one of the
preferred sites, with a significant impact in patients' quality of life. With the aim of delineating …

The complex interaction between hematopoietic stem cells (HSCs) and their
microenvironment in the human bone marrow ensures a life-long blood production by …