Patient-derived organoids as a stem cell model to study lung cancer

M Acosta-Plasencia, JJ Castellano, AM Taylor, Y He… - 2022 - Springer
Lung cancer is an extremely aggressive disease that remains the most common cause of
cancer-related death in the world. However, to date the lack of functional models that truly …

ROCK 'n TOR: an Outlook on keratinocyte Stem Cell Expansion in Regenerative Medicine via protein kinase Inhibition

G Centonze, S Centonze, L Ponzone, E Calautti - Cells, 2022 - mdpi.com
Keratinocyte stem cells play a fundamental role in homeostasis and repair of stratified
epithelial tissues. Transplantation of cultured keratinocytes autografts provides a landmark …

Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering

T Vikranth, T Dale, NR Forsyth - Journal of Tissue Engineering …, 2024 - Wiley Online Library
Persistent air leaks caused by thoracic surgery, physical trauma, or spontaneous
pneumothoraces are a cause of patient morbidity with need for extended chest tube …

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro

TP Dale, MD Santer, M Haris, W Zuo… - ExpErimEntal lung …, 2023 - Taylor & Francis
Purpose Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia
and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor pulmonale …

Immortalization and characterization of rat lingual keratinocytes in a high-calcium and feeder-free culture system using ROCK inhibitor Y-27632

Z Chen, W He, TCN Leung, HY Chung - International Journal of …, 2021 - mdpi.com
Cultured keratinocytes are desirable models for biological and medical studies. However,
primary keratinocytes are difficult to maintain, and there has been little research on lingual …

Hypoxic conditions promote a proliferative, poorly differentiated, and pro-secretory phenotype in COPD lung tissue progenitor cells in vitro

TP Dale, MD Santer, M Haris, W Zuo, NR Forsyth - bioRxiv, 2022 - biorxiv.org
Chronic obstructive pulmonary disease patients experience variable symptoms dependent
on the presence of an emphysematous versus a chronic bronchitis phenotype. Both …

Decellularisation and characterisation of porcine pleura for lung tissue engineering

T Vikranth, T Dale, NR Forsyth - bioRxiv, 2023 - biorxiv.org
Decellularisation offers a broad range of biomimetic scaffolds of allogeneic and xenogeneic
origins, exhibiting innate tissue-specific characteristics. We explored a physico-chemical …

Cell culture platforms to study ABCA-3 deficiency in vitro

N Shaw - 2021 - research-repository.uwa.edu.au
Dysfunction of type II alveolar cells due to deficiency in the lipid transporter protein, ATP-
binding cassette subfamily A member3 (ABCA-3), can cause lung disease in children. The …