Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

Abstract The 4D Nucleome Network aims to develop and apply approaches to map the
structure and dynamics of the human and mouse genomes in space and time with the goal …

A large number of putative cis-regulatory sequences have been annotated in the human
genome, but the genes they control remain poorly defined. To bridge this gap, we generate …

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

The three-dimensional configuration of DNA is integral to all nuclear processes in
eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide …

Abstract The Galaxy HiCExplorer provides a web service at https://hicexplorer. usegalaxy.
eu. It enables the integrative analysis of chromosome conformation by providing tools and …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Transcriptional control in large genomes often requires looping interactions between distal
DNA elements, such as enhancers and target promoters. Current chromosome conformation …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

HiCUP is a pipeline for processing sequence data generated by Hi-C and Capture Hi-C
(CHi-C) experiments, which are techniques used to investigate three-dimensional genomic …