Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Actin, spectrin, and associated molecules form a membrane-associated periodic skeleton
(MPS) in neurons. In the MPS, short actin filaments, capped by actin-capping proteins, form …

Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

Recent super-resolution microscopy studies have unveiled a periodic scaffold of actin rings
regularly spaced by spectrins under the plasma membrane of axons. However …

The corporeal beauty of the neuronal cytoskeleton has captured the imagination of
generations of scientists. One of the easiest cellular structures to visualize by light …

We recently developed expansion microscopy (ExM), which achieves nanoscale-precise
imaging of specimens at~ 70 nm resolution (with~ 4.5 x linear expansion) by isotropic …

Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …

The brain is our most complex organ. During development, neurons extend axons, which
may grow over long distances along well-defined pathways to connect to distant targets. Our …