The spectrum of malnutrition/cachexia/sarcopenia in oncology according to different cancer types and settings: a narrative review

P Bossi, P Delrio, A Mascheroni, M Zanetti - Nutrients, 2021 - mdpi.com
Nutritional status in oncological patients may differ according to several modifiable and non-
modifiable factors. Knowledge of the epidemiology of malnutrition/cachexia/sarcopenia may …

TGF-β signaling in the tumor metabolic microenvironment and targeted therapies

X Shi, J Yang, S Deng, H Xu, D Wu, Q Zeng… - Journal of Hematology & …, 2022 - Springer
Transforming growth factor-β (TGF-β) signaling has a paradoxical role in cancer
progression, and it acts as a tumor suppressor in the early stages but a tumor promoter in …

Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia

S Peixoto da Silva, JMO Santos… - Journal of cachexia …, 2020 - Wiley Online Library
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal
muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic …

Weight loss, malnutrition, and cachexia in COVID‐19: facts and numbers

MS Anker, U Landmesser… - Journal of cachexia …, 2021 - Wiley Online Library
Patients with COVID‐19 disease are prone to develop significant weight loss and clinical
cachexia. Three reports with altogether 589 patients that reported on weight loss and …

Gut microbiota and short‐chain fatty acid alterations in cachectic cancer patients

J Ubachs, J Ziemons, Z Soons… - Journal of cachexia …, 2021 - Wiley Online Library
Background Cancer cachexia is characterized by a negative energy balance, muscle and
adipose tissue wasting, insulin resistance, and systemic inflammation. Because of its strong …

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

V Rausch, V Sala, F Penna, PE Porporato, A Ghigo - Oncogenesis, 2021 - nature.com
Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

Inflammation and metabolism in cancer cell—mitochondria key player

M Neagu, C Constantin, ID Popescu, D Zipeto… - Frontiers in …, 2019 - frontiersin.org
Cancer metabolism is an essential aspect of tumorigenesis, as cancer cells have increased
energy requirements in comparison to normal cells. Thus, an enhanced metabolism is …

Mitochondrial dysfunction as an underlying cause of skeletal muscle disorders

TH Chen, KY Koh, KMC Lin, CK Chou - International journal of molecular …, 2022 - mdpi.com
Mitochondria are an important energy source in skeletal muscle. A main function of
mitochondria is the generation of ATP for energy through oxidative phosphorylation …

Chemotherapy-induced sarcopenia

F Bozzetti - Current treatment options in oncology, 2020 - Springer
Opinion statement Sarcopenia is being consistently recognized as a condition not only
associated with the presence of a malignancy but also induced by the oncologic therapies …

Phenotypic features of cancer cachexia‐related loss of skeletal muscle mass and function: lessons from human and animal studies

A Martin, D Freyssenet - Journal of cachexia, sarcopenia and …, 2021 - Wiley Online Library
Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility,
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …