[HTML][HTML] Molecular pathways that drive diabetic kidney disease
Kidney disease is a major driver of mortality among patients with diabetes and diabetic
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …
[HTML][HTML] Clinical relevance of globotriaosylceramide accumulation in Fabry disease and the effect of agalsidase beta in affected tissues
C Tøndel, BL Thurberg, P DasMahapatra, N Lyn… - Molecular Genetics and …, 2022 - Elsevier
Fabry disease (FD) is a rare lysosomal storage disorder, characterized by a reduction in α-
galactosidase A enzyme activity and the progressive accumulation of globotriaosylceramide …
galactosidase A enzyme activity and the progressive accumulation of globotriaosylceramide …
[HTML][HTML] Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development
Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …
development, as they not only reflect metabolic changes but are also preserved and …
Unbiased human kidney tissue proteomics identifies matrix metalloproteinase 7 as a kidney disease biomarker
D Hirohama, A Abedini, S Moon… - Journal of the …, 2023 - journals.lww.com
Background Diabetic kidney disease (DKD) is responsible for close to half of all ESKD
cases. Although unbiased gene expression changes have been extensively characterized in …
cases. Although unbiased gene expression changes have been extensively characterized in …
Value of multiparametric magnetic resonance imaging for evaluating chronic kidney disease and renal fibrosis
C Hua, L Qiu, L Zhou, Y Zhuang, T Cai, B Xu, S Hao… - European …, 2023 - Springer
Objectives To identify optimized MRI markers for evaluating chronic kidney disease (CKD)
and renal interstitial fibrosis (IF). Materials and methods This prospective study included 43 …
and renal interstitial fibrosis (IF). Materials and methods This prospective study included 43 …
Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression
Kidneys possess one of the most intricate three-dimensional cellular structures in the body,
yet the spatial and molecular principles of kidney health and disease remain inadequately …
yet the spatial and molecular principles of kidney health and disease remain inadequately …
[HTML][HTML] Kidney biopsy-based epidemiologic analysis shows growing biopsy rate among the elderly
Systematic registration and examination of biopsy-related data in Central and Eastern
Europe are scarce, while the health condition of the population is worse compared to other …
Europe are scarce, while the health condition of the population is worse compared to other …
Prognostic implications of a morphometric evaluation for chronic changes on all diagnostic native kidney biopsies
Background Semiquantitative visual inspection for glomerulosclerosis, interstitial fibrosis,
and arteriosclerosis is often used to assess chronic changes in native kidney biopsies …
and arteriosclerosis is often used to assess chronic changes in native kidney biopsies …
Circulating activin A, kidney fibrosis, and adverse events
MT Tsai, SM Ou, KH Lee, CC Lin… - Clinical Journal of the …, 2023 - journals.lww.com
Background: Identification of reliable biomarkers to assess kidney fibrosis severity is
necessary for patients with chronic kidney disease (CKD). Activin A, a member of the TGF-β …
necessary for patients with chronic kidney disease (CKD). Activin A, a member of the TGF-β …
[HTML][HTML] Plasma biomarkers as risk factors for incident CKD
Introduction Earlier identification of individuals at high risk of chronic kidney disease (CKD)
may facilitate improved risk factor mitigation. Methods We evaluated the association of novel …
may facilitate improved risk factor mitigation. Methods We evaluated the association of novel …