Kidney disease is a major driver of mortality among patients with diabetes and diabetic
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …

Fabry disease (FD) is a rare lysosomal storage disorder, characterized by a reduction in α-
galactosidase A enzyme activity and the progressive accumulation of globotriaosylceramide …

Background Diabetic kidney disease (DKD) is responsible for close to half of all ESKD
cases. Although unbiased gene expression changes have been extensively characterized in …

Kidneys possess one of the most intricate three-dimensional cellular structures in the body,
yet the spatial and molecular principles of kidney health and disease remain inadequately …

Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …

Background: Identification of reliable biomarkers to assess kidney fibrosis severity is
necessary for patients with chronic kidney disease (CKD). Activin A, a member of the TGF-β …

Systematic registration and examination of biopsy-related data in Central and Eastern
Europe are scarce, while the health condition of the population is worse compared to other …

Background Variable flip angle (VFA) and modified Look–Locker inversion recovery (MOLLI)
are frequently used for noninvasive evaluation of renal interstitial fibrosis (IF) in chronic …

Predicting the transition of kidney function in chronic kidney disease is difficult as specific
symptoms are lacking and often overlooked, and progress occurs due to complicating …

Background Semiquantitative visual inspection for glomerulosclerosis, interstitial fibrosis,
and arteriosclerosis is often used to assess chronic changes in native kidney biopsies …