Immuno-related gene transcription and antibody response in nodavirus (RGNNV and SJNNV)-infected European sea bass (Dicentrarchus labrax L.)

P Moreno, B Lopez-Jimena, E Randelli… - Fish & Shellfish …, 2018 - Elsevier
The immune response of European sea bass to RGNNV and SJNNV infections has been
evaluated by quantifying the transcription of some genes involved in the IFN I system, as …

Increase of viral hemorrhagic septicemia virus growth by knockout of IRF9 gene in Epithelioma papulosum cyprini cells

MS Kim, MJ Shin, KH Kim - Fish & shellfish immunology, 2018 - Elsevier
Viral hemorrhagic septicemia virus (VHSV) has been a notorious pathogen in freshwater
and marine fish. Due to the lack of effective treatment measures against VHSV disease, the …

Poly (I: C) and imiquimod induced immune responses and their effects on the survival of olive flounder (Paralichthys olivaceus) from viral haemorrhagic septicaemia

S Avunje, SJ Jung - Fish & Shellfish Immunology, 2017 - Elsevier
The stimulation of immune genes by polyinosinic: polycytidylic acid (poly (I: C)) and
imiquimod in olive flounder (Paralichthys olivaceus) and their role in control of viral …

Genetic characterization and transcription analyses of the European sea bass (Dicentrarchus labrax) isg15 gene

P Moreno, E Garcia-Rosado, JJ Borrego… - Fish & Shellfish …, 2016 - Elsevier
Fish interferons are cytokines involved in its resistance to viral infections by inducing the
transcription of several interferon-induced genes, such as isg15. The aim of the present …

[HTML][HTML] Cytokine-like activity of European sea bass ISG15 protein on RGNNV-infected E− 11 cells

P Moreno, R Leiva-Rebollo, E Garcia-Rosado… - Fish & Shellfish …, 2022 - Elsevier
IFN-I generates an antiviral state by inducing the expression of numerous genes, called IFN-
stimulated genes, ISGs, including ISG15, which is the only ISG with cytokine-like activity. In a …

A CgIFNLP receptor from Crassostrea gigas and its activation of the related genes in human JAK/STAT signaling pathway

R Zhang, R Liu, L Xin, H Chen, C Li, L Wang… - Developmental & …, 2016 - Elsevier
Interferon is a highly pleiotropic cytokine, once binding to its receptors, can activate JAK
kinases and STAT transcription factors to initiate the transcription of genes downstream from …

Identification of an interferon-stimulated gene, isg15, involved in host immune defense against viral infections in gilthead seabream (Sparus aurata L.)

D Álvarez-Torres, V Gómez-Abellán, M Arizcun… - Fish & shellfish …, 2018 - Elsevier
Interferons (IFNs) play a key role in the innate immunity of vertebrates against viral infections
by inducing hundreds of IFN-stimulated genes (ISGs), such as isg15. Isg15 is an ubiquitin …

Immune response of senegalese sole against betanodavirus mutants with modified virulence

J Gémez-Mata, S Souto, I Bandín, MC Alonso… - Pathogens, 2021 - mdpi.com
Nervous necrosis virus (NNV), genus Betanodavirus, the etiological agent of the viral
encephalopathy and retinopathy (VER), presents a genome with two positive-sense single …

Molecular characterization and expression analyses of the Solea senegalensis interferon-stimulated gene 15 (isg15) following NNV infections

D Álvarez-Torres, AM Podadera, MC Alonso… - Fish & Shellfish …, 2017 - Elsevier
Interferons are essential in fish resistance to viral infections. They induce interferon-
stimulated genes, such as isg15. In this study, the Senegalese sole isg15 gene (ssisg15) …

shRNAs targeting either the glycoprotein or polymerase genes inhibit Viral haemorrhagic septicaemia virus replication in zebrafish ZF4 cells

BD Clarke, KA McColl, AC Ward, TJ Doran - Antiviral Research, 2017 - Elsevier
Viral haemorrhagic septicaemia virus (VHSV) represents an important disease of finfish. To
explore the potential of shRNAs to combat this disease nucleotide sequences of either the …