[HTML][HTML] HIV-1 Tat: role in bystander toxicity
D Ajasin, EA Eugenin - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
HIV Tat protein is a critical protein that plays multiple roles in HIV pathogenesis. While its
role as the transactivator of HIV transcription is well established, other roles associated with …
role as the transactivator of HIV transcription is well established, other roles associated with …
HIV Tat, its TARgets and the control of viral gene expression
The human immunodeficiency virus (HIV-1)(transactivator of transcription (Tat)) protein is a
pleiotropic factor that induces a broad range of biological effects in numerous cell types. At …
pleiotropic factor that induces a broad range of biological effects in numerous cell types. At …
Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans
Tat, the transactivator protein of human immunodeficiency virus-1, has the unusual capacity
of being internalized by cells when present in the extracellular milieu. This property can be …
of being internalized by cells when present in the extracellular milieu. This property can be …
HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic …
HC Chang, F Samaniego, BC Nair, L Buonaguro… - Aids, 1997 - journals.lww.com
Objective: To investigate outbreaks of multidrug-resistant tuberculosis (TB) by using DNA
fingerprint databases. Design: Investigation of two outbreaks of multidrug-resistant TB in …
fingerprint databases. Design: Investigation of two outbreaks of multidrug-resistant TB in …
Control of SHIV-89.6 P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
A Cafaro, A Caputo, C Fracasso, MT Maggiorella… - Nature medicine, 1999 - nature.com
Vaccine strategies aimed at blocking virus entry have so far failed to induce protection
against heterologous viruses. Thus, the control of viral infection and the block of disease …
against heterologous viruses. Thus, the control of viral infection and the block of disease …
Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses
E Fanales-Belasio, S Moretti, F Nappi… - The Journal of …, 2002 - journals.aai.org
Vaccination of cynomolgus monkeys with the biologically active HIV-1 Tat protein induces
specific Th1 responses, including CTLs. Similar responses are also induced by vaccination …
specific Th1 responses, including CTLs. Similar responses are also induced by vaccination …
Contribution of nonneutralizing vaccine-elicited antibody activities to improved protective efficacy in rhesus macaques immunized with Tat/Env compared with …
RH Florese, T Demberg, P Xiao, LR Kuller… - The Journal of …, 2009 - journals.aai.org
Previously, chronic-phase protection against SHIV 89.6 P challenge was significantly
greater in macaques primed with replicating adenovirus type 5 host range mutant (Ad5hr) …
greater in macaques primed with replicating adenovirus type 5 host range mutant (Ad5hr) …
The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis
GR Campbell, E Pasquier, J Watkins… - Journal of Biological …, 2004 - ASBMB
Human immunodeficiency virus (HIV) infection and the progression to AIDS are
characterized by the depletion of CD4+ T-cells. HIV-1 infection leads to apoptosis of …
characterized by the depletion of CD4+ T-cells. HIV-1 infection leads to apoptosis of …
Vaccination with tat toxoid attenuates disease in simian/HIV-challenged macaques
CD Pauza, P Trivedi, M Wallace… - Proceedings of the …, 2000 - National Acad Sciences
The Tat protein is essential for HIV type 1 (HIV-1) replication and may be an important
virulence factor in vivo. We studied the role of Tat in viral pathogenesis by immunizing …
virulence factor in vivo. We studied the role of Tat in viral pathogenesis by immunizing …
Identification of a novel domain of HIV tat involved in monocyte chemotaxis
Human immunodeficiency virus (HIV) Tat is chemotactic for monocytes and dendritic cells,
an activity that could play a key role in the expansion of HIV infection of accessory cells. To …
an activity that could play a key role in the expansion of HIV infection of accessory cells. To …