[HTML][HTML] Opportunities and barriers in omics-based biomarker discovery for steatotic liver diseases

M Thiele, IF Villesen, L Niu, S Johansen, K Sulek… - Journal of …, 2024 - Elsevier
The rising prevalence of liver diseases related to obesity and excessive use of alcohol is
fuelling an increasing demand for accurate biomarkers aimed at community screening …

Non-invasive tests for alcohol-associated liver disease

M Israelsen, W Rungratanawanich, M Thiele… - Hepatology, 2024 - journals.lww.com
Alcohol consumption is a global phenomenon and a major contributor to alcohol-associated
liver disease (ALD). Detecting individuals at risk of ALD has been challenging, with only a …

[HTML][HTML] Low sphingolipid levels predict poor survival in patients with alcohol-related liver disease

TM Kronborg, Q Gao, K Trošt, H Ytting, MB O'Connell… - JHEP Reports, 2024 - Elsevier
Background & Aims Alcohol-related hepatitis (AH) and alcohol-related cirrhosis are grave
conditions with poor prognoses. Altered hepatic lipid metabolism can impact disease …

Genetic association analysis of dietary intake and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study

C Zhang, Y Xi, Y Zhang, P He, X Su, F Fan, M Wu… - BMC Pulmonary …, 2024 - Springer
Background IPF is a complex lung disease whose aetiology is not fully understood, but diet
may have an impact on its development and progression. Therefore, we investigated the …

[HTML][HTML] The Metabolomic Footprint of Liver Fibrosis

D Beyoğlu, YV Popov, JR Idle - Cells, 2024 - mdpi.com
Both experimental and clinical liver fibrosis leave a metabolic footprint that can be
uncovered and defined using metabolomic approaches. Metabolomics combines pattern …

[HTML][HTML] Plasma cathepsin D as an early indicator for alcohol-related liver disease

M Li, T Houben, AV Bitorina, DM Meesters, M Israelsen… - JHEP Reports, 2024 - Elsevier
Abstract Background & Aims People who excessively drink alcohol are at increased risk of
developing metabolic dysfunction and alcohol-related liver disease (MetALD) or the more …

Lipidomics and transcriptomics analysis revealed the role of the spleen of Nile tilapia (Oreochromis niloticus) in lipid metabolism

Y Tao, Y Chen, J Ren, S Jiang, S Zhang, H Xu, Y Li - Aquaculture, 2024 - Elsevier
In fish, the development of the spleen is not as perfect as that of higher vertebrates, but it has
the same functions that the spleen should have. Up to date, research on fish spleen is mostly …

[HTML][HTML] Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis

S Li, X Xue, H Zhang, L Jiang, Y Zhang, X Zhu… - Chemico-Biological …, 2024 - Elsevier
Acute lung injury (ALI) is a frequent complication of sepsis, with pyroptosis playing a pivotal
role. Analysis of Gene Expression Omnibus (GEO) mouse sepsis datasets revealed the …

Non-Invasive Biomarkers for Differentiating Alcohol Associated Hepatitis from Acute Decompensation in Patients with ALD

M Ignat, H Stefanescu - Journal of Clinical Medicine, 2024 - mdpi.com
Alcohol-associated hepatitis (AH) is the most severe form of alcohol-related liver disease.
The natural course of alcohol-related liver disease is influenced by heavy alcohol …

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

S Nishijima, E Stankevic, O Aasmets, TSB Schmidt… - bioRxiv, 2024 - biorxiv.org
The microbiota in individual habitats differ both in relative composition and absolute
abundance. While sequencing approaches determine only the relative abundances of taxa …