Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …

Short peptides have great potential as safe and effective anticancer drug leads. Herein, the
influence of short cyclic peptides containing the Pro-Pro-Phe-Phe sequence on patient …

Considering the increasing importance of cyclopropyl-containing peptide-derived
compounds in the pharmaceutical industry, herein, we report the crystal engineering of a …

Objective To purify an esterase which can selectively hydrolyze (R, S)-ethyl indoline-2-
carboxylate to produce (S)-indoline-2-carboxylic acid and characterize its enzymatic …

The crystal and molecular structure landscape of a new drug ticagrelor has been
investigated by using experimental and theoretical approach. The structures of this …

2, 5-diketopiperazines (DKP) are the simplest cyclo-peptides in nature, which could play a
key role in the origin of life. They are ubiquitous in microorganisms, higher species, and in …

Background: It is well documented in the scientific literature that high blood pressure can
lead to cardiovascular disease. Untreated hypertension has clinical consequences such as …

Proline is a unique, endogenous amino acid, prevalent in proteins and essential for living
organisms. It is appreciated as a tecton for the rational design of new bio-active substances …

Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC)
is a powerful approach in the fight against diverse viruses, including SARS-CoV-2 …