[HTML][HTML] Drug-induced oxidative stress in cancer treatments: Angel or devil?

H Jiang, J Zuo, B Li, R Chen, K Luo, X Xiang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

D Ezhilarasan - Toxicology, 2021 - Elsevier
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

Netrin-1 alleviates early brain injury by regulating ferroptosis via the PPARγ/Nrf2/GPX4 signaling pathway following subarachnoid hemorrhage

J Chen, Y Wang, M Li, X Zhu, Z Liu, Q Chen… - Translational stroke …, 2024 - Springer
Subarachnoid hemorrhage (SAH) is a type of stroke with high morbidity and mortality. Netrin-
1 (NTN-1) can alleviate early brain injury (EBI) following SAH by enhancing peroxisome …

Echinacea purpurea Fractions Represent Promising Plant-Based Anti-Inflammatory Formulations

SF Vieira, SM Gonçalves, VMF Gonçalves, CP Llaguno… - Antioxidants, 2023 - mdpi.com
Echinacea purpurea is traditionally used in the treatment of inflammatory diseases.
Therefore, we investigated the anti-inflammatory capacity of E. purpurea dichloromethanolic …

Echinacea in hepatopathy: A review of its phytochemistry, pharmacology, and safety

W Xu, H Zhu, B Hu, Y Cheng, Y Guo, W Yao, H Qian - Phytomedicine, 2021 - Elsevier
Background Echinacea, one of the most popular herbs with double function of immunity and
anti-inflammatory activity, has now attracted much interest for a possible alternative for the …

[HTML][HTML] In ovo protective effects of chicoric and rosmarinic acids against Thiacloprid-induced cytotoxicity, oxidative stress, and growth retardation on newly hatched …

MR Farag, C Zizzadoro, M Alagawany, SM Abou-Zeid… - Poultry Science, 2023 - Elsevier
Thiacloprid (TH) is a neonicotinoid insecticide employed in agriculture to protect fruits and
vegetables against different insects. It showed different deleterious effects on the general …

The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced …

B Varışlı, C Caglayan, FM Kandemir, C Gür… - Molecular Biology …, 2022 - Springer
Background Methotrexate (MT) is a broadly used chemotherapeutic drug however its clinical
use is confronted with several forms of toxicities containing testicular damage. The current …

Polyphenolic Characterization and Anti-Inflammatory Effect of In Vitro Digested Extracts of Echinacea purpurea L. Plant Parts in an Inflammatory Model of Human …

MÁ Ávila-Gálvez, JA Giménez-Bastida… - International Journal of …, 2024 - mdpi.com
Echinacea purpurea L.(EP) preparations are globally popular herbal supplements known for
their medicinal benefits, including anti-inflammatory activities, partly related to their phenolic …

Galangin attenuates liver injury, oxidative stress and inflammation, and upregulates Nrf2/HO-1 signaling in streptozotocin-induced diabetic rats

W Al-Amarat, MH Abukhalil, OY Althunibat… - Processes, 2021 - mdpi.com
Chronic hyperglycemia increases the risk of liver damage. Oxidative stress and aberrant
inflammatory response are entangled in diabetes-associated liver injury. This study …

Spirulina and thymoquinone protect against methotrexate-induced hepatic injury in rats

A Behairy, A Elkomy, F Elsayed, MMS Gaballa… - Revista Brasileira de …, 2024 - Springer
Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer.
The purpose of this research was to examine if the administration of Arthrospira platensis …