Protein tyrosine phosphatase SHP2 mediates RAS-driven MAPK signaling and has
emerged in recent years as a target of interest in oncology, both for treating with a single …

Accurate prediction of human clearance (CL) and volume of distribution at steady state (Vd,
ss) for small molecule drug candidates is an essential component of assessing likely …

Highlights•Allometric scaling is suitable for prediction of human renal drug clearance
(CLr).•The average CLr of a diverse set of 20 drugs scales to the ¾ power of body mass.•Rat …

For almost fifteen years, the availability and regulatory acceptance of new approach
methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion …

With an increasing need to incorporate new approach methodologies (NAMs) in chemical
risk assessment and the concomitant need to phase out animal testing, the interpretation of …

Autoreactive B cell-derived antibodies form immune complexes that likely play a pathogenic
role in autoimmune diseases. In systemic lupus erythematosus (SLE), these antibodies bind …

Improved pharmacokinetics/pharmacodynamics (PK/PD) prediction in the early stages of
drug development is essential to inform lead optimization strategies and reduce attrition …

The two fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine (4F-Cy-
BAP) and furanoyl-1-benzyl-4-anilinopiperidine (Fu-BAP) have recently been seized as new …

This review presents materials characterizing sulfated polysaccharides (SPS) of marine
hydrobionts (algae and invertebrates) as potential means for the prevention and treatment of …

As a toxic substance, 4-n-nonylphenol (4-n-NP) or 4-nonylphenol (4-NP) is widely present in
the environment. 4-n-NP is a single substance with a linear-alkyl side chain, but 4-NP …