Alternatives to efficient viral vectors in gene therapy are desired because of their poor safety profiles. Chitosan is a promising non-viral nucleotide delivery vector because of its …
A Almeida, M Araujo, R Novoa-Carballal… - Materials Science and …, 2020 - Elsevier
Chitosan was grafted with O-methyl-O′-succinylpolyethylene glycol and oleic acid after a two-step carbodiimide coupling. The structural and physicochemical characterization of the …
Chitosan is a complex linear amino co-polymer which, depending on a great variety of parameters, exhibits a more or less amphiphilic structure. This makes this polysaccharide …
Chitosan nanoparticles crosslinked with genipin were prepared by reverse microemulsion that allowed to obtain highly monodisperse (3–20nm by TEM) nanogels. The incorporation …
DN Carvalho, M Gelinsky, DS Williams… - International Journal of …, 2023 - Elsevier
Cartilage repair after a trauma or a degenerative disease like osteoarthritis (OA) continues to be a big challenge in current medicine due to the limited self-regenerative capacity of the …
G Lamarque, JM Lucas, C Viton, A Domard - Biomacromolecules, 2005 - ACS Publications
Physicochemical properties of four different homogeneous series of chitosans with degrees of acetylation (DA) and weight-average degrees of polymerization (DPw) ranging from 0 to …
LMB Ferreira, AM Dos Santos, FI Boni… - Carbohydrate …, 2020 - Elsevier
Chitosan-based particles are widely proposed as biocompatible drug delivery systems with mucoadhesive and permeation enhancing properties. However, strategies on how to …
OE Philippova, EV Korchagina - Polymer Science Series A, 2012 - Springer
This review surveys the main methods of preparing chitosan and its hydrophobic derivatives and their influence on the microstructure of polymers. The experimental data on the …
Combating melanoma via topical route is a highly challenging task due to low selectivity, poor efficacy and impeding biological environment of the skin. In the present study, we …