Background: Prevention and management of end-organ disease represent major
challenges facing providers of children and adults with sickle cell disease (SCD) …

A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is
evident in the lung, where both systems must be properly controlled to maintain lung …

Acute chest syndrome (ACS) is a leading cause of respiratory distress and hospitalisation in
children with sickle cell disease (SCD). The aetiology is multifactorial and includes fat …

Sickle cell disease (SCD) is a complex, clinically heterogeneous disorder affecting
approximately 100,000 individuals in the United States and millions worldwide. The disease …

Introduction: the spectrum of pulmonary complications in sickle cell anemia (SCA) comprises
mainly of acute chest syndrome (ACS), pulmonary hypertension (PH) and Airway hyper …

Background: Pulmonary complications of sickle cell disease (SCD) are diverse and
encompass acute and chronic disease. The understanding of the natural history of …

Median life expectancy of patients with sickle cell disease has increased to up to 55 years
but there are still frequent cases of premature death, mostly in patients with pre-existing …

Sickle cell disease (SCD) is a life-threatening hereditary blood disorder that affects millions
of people worldwide, especially in sub-Saharan Africa. This condition has a multi-organ …

Rationale: Patient factors associated with development of abnormal lung function in children
with sickle cell anemia (SCA) have not been fully characterized. Objectives: To characterize …

Background Acute chest syndrome (ACS) is an acute complication in SCD but its effects on
lung function are not well understood. Inflammation is a key component of SCD …