Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

Precise monitoring of internal temperature is vital for thermal homeostasis in mammals. For
decades, warm-sensitive neurons (WSNs) within the preoptic area (POA) were thought to …

Transient receptor potential (TRP) channels are a family of cation channels that depolarizes
the membrane potential and regulates intracellular concentrations of cations such as Ca 2+ …

The post-genomic era has seen many advances inBaryza and G. Rice for helpful our
understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate …

TRPC5 channel is a nonselective cation channel that participates in diverse physiological
processes. TRPC5 inhibitors show promise in the treatment of anxiety disorder, depression …

Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential
cation channel, subfamily C, member 6) were linked to development of familial forms of …

Since the discovery of the participation of various ion channels in the regulation of cell
proliferation and programmed cell death two decades ago, the field exploring ion channel …

Canonical transient receptor potential channels (TRPC) are involved in receptor-operated
and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to …