Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …

Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory
neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic …

Small‐fiber neuropathy (SFN) is a disorder of thinly myelinated Aδ and unmyelinated C
fibers. SFN is clinically dominated by neuropathic pain and autonomic complaints, leading to …

Acute pain is adaptive, but chronic pain is a global challenge. Many chronic pain syndromes
are peripheral in origin and reflect hyperactivity of peripheral pain-signaling neurons …

Voltage-gated sodium channels NaV1. 7, NaV1. 8 and NaV1. 9 have been the focus for pain
studies because their mutations are associated with human pain disorders, but the role of …

Voltage-gated sodium ion channel subtype 1.7 (NaV1. 7) is a high interest target for the
discovery of non-opioid analgesics. Compelling evidence from human genetic data …

Pain is a complex process that involves both detection in the peripheral nervous system and
perception in the CNS. Individual-to-individual differences in pain are well documented, but …

The utilization of local anesthetics for postoperative analgesia represents an effective
approach, but generally suffers from short half‐lives and brachychronic local neurotoxicity. A …

Trigeminal neuralgia (TN) is a unique pain disorder characterized by intense paroxysmal
facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are …