Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications

K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …

Non-coding RNAs in breast cancer: intracellular and intercellular communication

CM Klinge - Non-coding RNA, 2018 - mdpi.com
Non-coding RNAs (ncRNAs) are regulators of intracellular and intercellular signaling in
breast cancer. ncRNAs modulate intracellular signaling to control diverse cellular processes …

Importin α: a key molecule in nuclear transport and non-transport functions

Y Miyamoto, K Yamada, Y Yoneda - The journal of biochemistry, 2016 - academic.oup.com
Importin α performs the indispensable role of ferrying proteins from the cytoplasm into the
nucleus with a transport carrier, importin β1. Mammalian cells from mouse or human contain …

Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer

K Miyamoto, N Seki, R Matsushita, M Yonemori… - British journal of …, 2016 - nature.com
Background: Previous studies have revealed that miR-26a-5p and miR-26b-5p act as
tumour suppressors in various types of cancer tissues. Here, we aimed to investigate the …

MicroRNA-based therapy and breast cancer: A comprehensive review of novel therapeutic strategies from diagnosis to treatment

PJ Kaboli, A Rahmat, P Ismail, KH Ling - Pharmacological research, 2015 - Elsevier
Abstract MicroRNAs (miRNA) are 21–23 nucleotide molecules not translated into proteins
that bind and target the 3′ untranslated regions of mRNA. These characteristics make them …

HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells

CM Klinge, KM Piell, CS Tooley, EC Rouchka - Scientific reports, 2019 - nature.com
MicroRNAs are dysregulated in breast cancer. Heterogeneous Nuclear Ribonucleoprotein
A2/B1 (HNRNPA2/B1) is a reader of the N (6)-methyladenosine (m6A) mark in primary …

The emerging roles of KPNA2 in cancer

Y Han, X Wang - Life sciences, 2020 - Elsevier
Abstract Karyopherin α2 (KPNA2, also known as importinα-1), a member of the nuclear
transporter family, is involved in the nucleocytoplasmic transport pathway of a variety of …

Identification of MicroRNAs as breast cancer prognosis markers through the cancer genome atlas

JTH Chang, F Wang, W Chapin, RS Huang - PloS one, 2016 - journals.plos.org
Breast cancer is the second-most common cancer and second-leading cause of cancer
mortality in American women. The dysregulation of microRNAs (miRNAs) plays a key role in …

Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease

A Alendar, A Berns - Genes & Development, 2021 - genesdev.cshlp.org
Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …

miR-26 family and its target genes in tumorigenesis and development

C Li, Y Li, Y Lu, Z Niu, H Zhao, Y Peng, M Li - Critical Reviews in Oncology …, 2021 - Elsevier
The microRNA-26 family, including miR-26a, miR-26b, miR-1297 and miR-4465, is a group
of broadly conserved small RNAs with identical sequences at the seed region. The …