Over the past 2 decades, the syndrome of heart failure with preserved ejection fraction
(HFpEF) received a lot of attention. 1–19 However, little therapeutic progress was made. 20 …

The burden of heart failure (HF) increases worldwide with an aging population, and there is
a high unmet medical need in both, heart failure with reduced ejection fraction (HFrEF) and …

Background—The prevalence and clinical significance of right ventricular (RV) systolic
dysfunction (RVD) in patients with heart failure and preserved ejection fraction (HFpEF) are …

Pulmonary hypertension (PH) is a frequent complication of left heart disease arising from a
wide range of cardiac disorders. In the clinical classification, PH associated with left heart …

Heart failure (HF) with preserved ejection fraction (HFpEF) is an increasingly frequent form
and is estimated to be the dominant form of HF. On the other hand, HFpEF is a syndrome …

Right ventricular (RV) failure is a complex problem with poor outcomes. Diagnosis requires
a high degree of clinical suspicion, because many of the signs and symptoms of this …

Objectives: This study sought to define the prognostic significance and clinical determinants
of the 6-min walk distance (6-MWD) in affected patients. Background: Symptoms of …

BACKGROUND: The term “obesity paradox”, refers to lower mortality rates in obese patients,
and is evident in various chronic cardiovascular disorders. There is however, only scarce …

Importance Despite pathophysiological links between endothelin-1 and pulmonary vascular
remodeling, to our knowledge, the association between plasma endothelin-1 levels and …

Emerging data suggest that noninvasive voice biomarker analysis is associated with
coronary artery disease. We recently showed that a vocal biomarker was associated with …