Apolipoprotein E (APOE) is a multifunctional protein synthesized and secreted by multiple
mammalian tissues. Although hepatocytes contribute about 75% of the peripheral pool …

Apolipoprotein E (APOE) is a member of the vertebrate protein family of exchangeable
apolipoproteins that is characterized by amphipathic α-helices encoded by multiple …

In many populations, the a polipoprotein-ε 4 (APOE-ε 4) allele increases the risk for several
chronic diseases of aging, including dementia and cardiovascular disease; despite these …

Few researchers would dispute that the pandemic of obesity is caused by a profound
mismatch between humanity's present environmental circumstances and those that have …

Williams' evolutionary theory of senescence based on antagonistic pleiotropy has become a
landmark in evolutionary biology, and more recently in biogerontology and evolutionary …

Between the 1930s and 1950s, scientists developed key principles of population genetics to
try and explain the aging process. Almost a century later, these aging theories, including …

Alzheimer's disease (AD) is characterized by numerous sexual dimorphisms that impact the
development, progression, and probably the strategies to prevent and treat the most …

Background The apolipoprotein-ε4 allele (APOE-ε4) is strongly associated with detrimental
outcomes in affluent populations including atherosclerotic disease, Alzheimer's disease, and …

The alleles that are detrimental to health, especially in older age, are thought to persist in
populations because they also confer some benefits for individuals (through antagonistic …

The elucidation of the molecular basis of familial hypercholesterolemia (FH) by Brown and
Goldstein about three decades ago provided the most convincing evidence for a causative …