Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or
activity can significantly alter the infection process, and enzyme expression profiles can be a …

As healthcare improves and our ability to support patients with compromised immune
systems increases, such patients become more vulnerable to microbes in the environment …

Meningitis due to Cryptococcus neoformans is responsible for upwards of 180,000 deaths
worldwide annually, mostly in immunocompromised individuals. Currently there are no …

Fungi of the Paracoccidioides genus are the etiological agents of paracoccidioidomycosis
(PCM), a systemic mycosis restricted to the countries of Latin America. Currently, the …

The opportunistic fungal pathogen Cryptococcus neoformans is a major cause of mortality in
immunocompromised individuals, resulting in more than 600,000 deaths per year. Many …

Therapeutic lumbar punctures are a critical part of cryptococcal meningitis management and
CSF immunological assays are increasingly being performed in research settings. Finer …

Paracoccidioides is a thermodimorphic fungus that causes Paracoccidioidomycosis (PCM)–
an endemic systemic mycosis in Latin America. The genus comprises several phylogenetic …

Highlights•Many fungal amino acid biosynthetic pathways are conserved in microbes but
absent from humans.•Several of the involved enzymes have now been found to be essential …

Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal
hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and …

The controversially discussed taxonomy of the Cryptococcus neoformans/Cryptococcus
gattii species complex encompasses at least eight major molecular types. Cerebral …