Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

Ectonucleotidases are key for purinergic signaling. They control the duration of activity of
purinergic receptor agonists. At the same time, they produce hydrolysis products as …

Geoffrey Burnstock will be remembered as the scientist who set up an entirely new field of
intercellular communication, signaling via nucleotides. The signaling cascades involved in …

CD73, a cell surface 5′ nucleotidase that generates adenosine, has emerged as an
attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment …

Immune escape is the main reason that immunotherapy is ineffective in hepatocellular
carcinoma (HCC). Here, this study illustrates a pathway mediated by neutrophil extracellular …

The search for new and effective treatment targets for cancer immunotherapy is an ongoing
challenge. Alongside the more established inhibitory immune checkpoints, a novel potential …

Simple Summary Tumors are ecosystems composed of cancer cells and non-tumor stroma
together in a hypoxic environment often described as wounds that do not heal. Accumulating …

Background Myocardial inflammation and apoptosis induced by cirrhosis are among the
primary mechanisms of cirrhotic cardiomyopathy. CD73, a common extracellular …

Schistosomiasis is a neglected tropical disease. Egg-induced granuloma formation and
tissue fibrosis are the main causes of the high morbidity and mortality of schistosomiasis …

CD39 (nucleoside triphosphate diphosphohydrolase) and Ecto-5-nucleotidase (CD73) have
been recognized as important factors mediating various pathological and physiological …