A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …
transformation. This is key to developing more efficient cancer detection methods and …
Wilms tumour
F Spreafico, CV Fernandez, J Brok, K Nakata… - Nature Reviews …, 2021 - nature.com
Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …
[HTML][HTML] A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism
The domestic cat (Felis catus) numbers over 94 million in the USA alone, occupies
households as a companion animal, and, like humans, suffers from cancer and common and …
households as a companion animal, and, like humans, suffers from cancer and common and …
Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children's Oncology Group AREN18B5-Q
Developing synchronous bilateral Wilms tumor suggests an underlying (epi) genetic
predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or …
predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or …
Prevalence of (epi) genetic predisposing factors in A 5-year unselected national Wilms tumor cohort: a comprehensive clinical and genomic characterization
JA Hol, RP Kuiper, F Van Dijk, E Waanders… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Wilms tumor (WT) is associated with (epi) genetic predisposing factors affecting a
growing number of WT predisposing genes and loci, including those causing Beckwith …
growing number of WT predisposing genes and loci, including those causing Beckwith …
New approaches to risk stratification for Wilms tumor
MV Nelson, MM van den Heuvel-Eibrink… - Current opinion in …, 2021 - journals.lww.com
New approaches to risk stratification for Wilms tumor : Current Opinion in Pediatrics New
approaches to risk stratification for Wilms tumor : Current Opinion in Pediatrics Log in or …
approaches to risk stratification for Wilms tumor : Current Opinion in Pediatrics Log in or …
Genetic predisposition to solid pediatric cancers
M Capasso, A Montella, M Tirelli, T Maiorino… - Frontiers in …, 2020 - frontiersin.org
Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …
scale analyses—including high-density genotyping and exome and genome sequencing …
The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics
Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …
Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome
SEM Stephenson, G Costain, LER Blok, MA Silk… - The American Journal of …, 2022 - cell.com
Neurodevelopmental disorders are highly heterogenous conditions resulting from
abnormalities of brain architecture and/or function. FBXW7 (F-box and WD-repeat-domain …
abnormalities of brain architecture and/or function. FBXW7 (F-box and WD-repeat-domain …
Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor
L Cai, B Shi, K Zhu, X Zhong, D Lai, J Wang, J Tou - Scientific Reports, 2023 - nature.com
Wilms tumor (WT) is the most common pediatric renal malignant tumor in the world. Overall,
the prognosis of Wilms tumor is very good. However, the prognosis of patients with …
the prognosis of Wilms tumor is very good. However, the prognosis of patients with …