The structure and function of paraoxonase-1 and its comparison to paraoxonase-2 and-3
A Taler-Verčič, M Goličnik, A Bavec - Molecules, 2020 - mdpi.com
Serum paraoxonase-1 (PON1) is the most studied member of the group of paraoxonases
(PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and …
(PONs). This enzyme possesses three enzymatic activities: lactonase, arylesterase, and …
Design, synthesis, biological evaluation and molecular docking studies of novel 1H-1, 2, 3-Triazole derivatives as potent inhibitors of carbonic anhydrase …
Triazole compounds have garnered significant interest due to their wide range of
pharmacological activities and ease of synthesis. Click chemistry is a synthetic method …
pharmacological activities and ease of synthesis. Click chemistry is a synthetic method …
Assessment of hypolipidemic and anti‐inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton …
Atherosclerosis and cognitive impairment are both influenced by hyperlipidemia. Due to
their high margin of safety and low cost, natural chemicals have recently attracted particular …
their high margin of safety and low cost, natural chemicals have recently attracted particular …
The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide‐induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic …
Abstract Chrysin (CH) or 5, 7‐dihydroxyflavone is a flavonoid present in various plants, bee
propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is …
propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is …
Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity
In the current study, some phenolic compounds, including acteoside, isoacteoside,
echinacoside, and arenarioside purified and characterized from Plantago subulata. These …
echinacoside, and arenarioside purified and characterized from Plantago subulata. These …
Naphthoquinones, benzoquinones, and anthraquinones: Molecular docking, ADME and inhibition studies on human serum paraoxonase‐1 associated with …
Y Demir - Drug development research, 2020 - Wiley Online Library
Abstract Paraoxonase‐1 (PON1) has essential roles such as protecting low‐density
lipoprotein against detoxification and oxidation of highly toxic compounds. Quinones are a …
lipoprotein against detoxification and oxidation of highly toxic compounds. Quinones are a …
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
Aldose reductase (AR) is a crucial enzyme of the polyol pathway through which glucose is
metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic …
metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic …
Some calcium-channel blockers: kinetic and in silico studies on paraoxonase-I
C Türkeş, Y Demir, Ş Beydemir - Journal of Biomolecular Structure …, 2022 - Taylor & Francis
Many drugs, which are used in clinical treatments, show pharmacological effects on enzyme
activity with an essential role in the pathogenesis of various diseases. Paraoxonase-I …
activity with an essential role in the pathogenesis of various diseases. Paraoxonase-I …
Biological evaluation and in silico study of benzohydrazide derivatives as paraoxonase 1 inhibitors
IN Korkmaz, C Türkeş, Y Demir… - … of Biochemical and …, 2022 - Wiley Online Library
Abstract Serum paraoxonase 1 (PON1) is found in all mammalian species and is a calcium‐
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
dependent hydrolytic enzyme. PON1 hydrolyze several substrates, including carbonates …
The behaviour of some antihypertension drugs on human serum paraoxonase-1: an important protector enzyme against atherosclerosis
Y Demir - Journal of pharmacy and pharmacology, 2019 - academic.oup.com
Abstract Objectives Paraoxonase-1 (PON1) enzyme is related to high-density lipoprotein
(HDL), which is calcium dependent. It has essential roles such as protecting LDL against …
(HDL), which is calcium dependent. It has essential roles such as protecting LDL against …