Enzymes and mechanisms employed by tailed bacteriophages to breach the bacterial cell barriers

S Fernandes, C São-José - Viruses, 2018 - mdpi.com
Monoderm bacteria possess a cell envelope made of a cytoplasmic membrane and a cell
wall, whereas diderm bacteria have and extra lipid layer, the outer membrane, covering the …

Phage-derived peptidoglycan degrading enzymes: challenges and future prospects for in vivo therapy

H Oliveira, C São-José, J Azeredo - Viruses, 2018 - mdpi.com
Peptidoglycan degrading enzymes are of increasing interest as antibacterial agents,
especially against multi-drug resistant pathogens. Herein we present a review about the …

Engineering of phage-derived lytic enzymes: improving their potential as antimicrobials

C São-José - Antibiotics, 2018 - mdpi.com
Lytic enzymes encoded by bacteriophages have been intensively explored as alternative
agents for combating bacterial pathogens in different contexts. The antibacterial character of …

Distribution and genomic characterization of tigecycline-resistant tet(X4)-positive Escherichia coli of swine farm origin

Y Li, Q Wang, K Peng, Y Liu, X Xiao… - Microbial …, 2021 - microbiologyresearch.org
The emergence of plasmid-mediated tigecycline-resistant strains is posing a serious threat
to food safety and human health, which has attracted worldwide attention. The tigecycline …

Synthetic antimicrobial peptides as enhancers of the bacteriolytic action of staphylococcal phage endolysins

A Gouveia, D Pinto, H Veiga, W Antunes, MG Pinho… - Scientific Reports, 2022 - nature.com
Bacteriophage endolysins degrade the bacterial cell wall and are therefore considered
promising antimicrobial alternatives to fight pathogens resistant to conventional antibiotics …

[HTML][HTML] Isolation and characterization of the Staphylococcus aureus bacteriophage vB_SauS_SA2

J Wang, F Zhao, H Sun, Q Wang, C Zhang… - AIMS …, 2019 - ncbi.nlm.nih.gov
A novel bacteriophage vB_SauS_SA2 (hereafter designated SA2) that infects
Staphylococcus aureus was isolated. At a multiplicity of infection (MOI) of 0.1, phage SA2 …

Deciphering the role of holin in mycobacteriophage D29 physiology

VR Bavda, V Jain - Frontiers in Microbiology, 2020 - frontiersin.org
In the era of antibiotic resistance, phage therapy is gaining attention for the treatment of
pathogenic organisms such as Mycobacterium tuberculosis. The selection of phages for …

Three Novel Bacteriophages, J5a, F16Ba, and z1a, Specific for Bacillus anthracis, Define a New Clade of Historical Wbeta Phage Relatives

A Nakonieczna, P Rutyna, M Fedorowicz, M Kwiatek… - Viruses, 2022 - mdpi.com
Bacillus anthracis is a potent biowarfare agent, able to be highly lethal. The bacteria dwell in
the soil of certain regions, as natural flora. Bacteriophages or their lytic enzymes, endolysins …

Development of a bacterial FhuD-Lysozyme-SsrA mediated Autolytic (FLSA) system for effective release of intracellular products

F Zhang, X Fan, K Xu, S Wang, S Shi, L Yi… - ACS Synthetic …, 2022 - ACS Publications
Developing effective bacterial autolytic systems for fast release of intracellular bioproducts
could simplify purification procedures and help with the high throughput screening of mutant …

On the occurrence and multimerization of two-polypeptide phage endolysins encoded in single genes

D Pinto, R Gonçalo, M Louro, MS Silva… - Microbiology …, 2022 - Am Soc Microbiol
Bacteriophages (phages) and other viruses are extremely efficient in packing their genetic
information, with several described cases of overlapping genes encoded in different open …