Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …
JA Clayton - New England Journal of Medicine, 2018 - Mass Medical Soc
Dry Eye Dry eye is a common, painful ocular disturbance that can result from systemic inflammatory diseases, localized eye problems, or commonly used medications. Current …
G Sollberger, DO Tilley, A Zychlinsky - Developmental cell, 2018 - cell.com
Neutrophils are essential to the homeostatic mission of safeguarding host tissues, responding rapidly and diversely to breaches of the host's barriers to infection, and returning …
Most patients with chronic dry eye disease (DED) have episodic flares, which can be triggered by a variety of activities and environmental stresses. These flares are typically …
L Wang, X Zhou, Y Yin, Y Mai, D Wang… - Frontiers in …, 2019 - frontiersin.org
Neutrophil extracellular traps (NETs), the product of NETosis, is found to localize pathogens and crystals in immune response. Recent studies have found that excessive NETs lead to …
J Singh, M Boettcher, M Dölling, A Heuer… - Cell Death & …, 2023 - nature.com
Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an important element that propels the pathological progression of a plethora of diseases. DNA …
P Rosenthal, D Borsook - British Journal of Ophthalmology, 2016 - bjo.bmj.com
As the biological alarm of impending or actual tissue damage, pain is essential for our survival. However, when it is initiated and/or sustained by dysfunctional elements in the …
Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for …
S An, I Raju, B Surenkhuu, JE Kwon, S Gulati… - The ocular …, 2019 - Elsevier
Purpose To investigate the role of neutrophil extracellular traps (NETs) and NET-associated proteins in the pathogenesis of oGVHD and whether dismantling of NETs with heparin …