Endometriosis is a chronic systemic disease: clinical challenges and novel innovations

HS Taylor, AM Kotlyar, VA Flores - The Lancet, 2021 - thelancet.com
Endometriosis is a common disease affecting 5–10% of women of reproductive age globally.
However, despite its prevalence, diagnosis is typically delayed by years, misdiagnosis is …

A lifelong impact on endometriosis: pathophysiology and pharmacological treatment

LH Chen, WC Lo, HY Huang, HM Wu - International Journal of Molecular …, 2023 - mdpi.com
Endometriosis is a chronic inflammatory disease associated with bothersome symptoms in
premenopausal women and is complicated with long-term systemic impacts in the post …

Progesterone receptor status predicts response to progestin therapy in endometriosis

VA Flores, A Vanhie, T Dang… - The Journal of Clinical …, 2018 - academic.oup.com
Context Progestin-based therapy is the first-line treatment for managing endometriosis-
associated pain. However, response to progestins is currently variable and unpredictable …

[HTML][HTML] Emerging hallmarks of endometriosis metabolism: a promising target for the treatment of endometriosis

J Lu, X Ling, L Liu, A Jiang, C Ren, C Lu… - Biochimica et Biophysica …, 2023 - Elsevier
Endometriosis, characterized by ectopic endometrium growth in the extrauterine
environment, is one of the most notable diseases of the female reproductive system …

Endometriosis and cardiovascular disease

B Marchandot, A Curtiaud, K Matsushita… - … heart journal open, 2022 - academic.oup.com
Endometriosis is a chronic gynaecological disease affecting 1 in 10 reproductive-age
women. It is defined as the presence of endometrium-like tissue outside the uterus. Beyond …

[HTML][HTML] Human epidemiological evidence about the associations between exposure to organochlorine chemicals and endometriosis: Systematic review and meta …

G Cano-Sancho, S Ploteau, K Matta, E Adoamnei… - Environment …, 2019 - Elsevier
Background Endometriosis is a gynaecological disease characterized by the presence of
ectopic endometrial tissue that affects women during their reproductive years, having a …

Is stress a cause or a consequence of endometriosis?

FM Reis, LM Coutinho, S Vannuccini, S Luisi… - Reproductive …, 2020 - Springer
Clinical studies clearly indicate that endometriosis is a condition associated with high levels
of chronic stress. The stress intensity correlates with pain severity and disease extension …

Metabolic profile of patients with severe endometriosis: a prospective experimental study

F Murgia, S Angioni, MN D'Alterio, S Pirarba… - Reproductive …, 2021 - Springer
Endometriosis is a common disease affecting women in reproductive age. There are several
hypotheses on the pathogenesis of this disease. Often, its lesions and symptoms overlap …

Systemic inflammation induced by microRNAs: endometriosis-derived alterations in circulating microRNA 125b-5p and Let-7b-5p regulate macrophage cytokine …

SE Nematian, R Mamillapalli… - The Journal of …, 2018 - academic.oup.com
Context Endometriosis is characterized by aberrant inflammation. We previously reported
increased levels of microRNA (miRNA) 125b-5p and decreased levels of miRNA Let-7b-5p …

From retrograde menstruation to endometrial determinism and a brave new world of “root treatment” of endometriosis: destiny or a fanciful utopia?

SW Guo, M Habiba, G Benagiano - Biomolecules, 2023 - mdpi.com
Practically unknown outside of China, the “endometrial determinism” theory was proposed to
account for the apparent gap between the relatively low prevalence of endometriosis and …