Drug treatments for covid-19: living systematic review and network meta-analysis
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …
How COVID-19 has fundamentally changed clinical research in global health
JJH Park, R Mogg, GE Smith… - The Lancet Global …, 2021 - thelancet.com
COVID-19 has had negative repercussions on the entire global population. Despite there
being a common goal that should have unified resources and efforts, there have been an …
being a common goal that should have unified resources and efforts, there have been an …
Efficacy of antiviral therapies for COVID-19: a systematic review of randomized controlled trials
CTR Vegivinti, KW Evanson, H Lyons, I Akosman… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) continues to pose a significant
threat to public health worldwide. The purpose of this study was to review current evidence …
threat to public health worldwide. The purpose of this study was to review current evidence …
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
ABSTRACT Introduction: The current SARS-CoV-2 pandemic urgently demands for both
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
An overview on the treatments and prevention against COVID-19
Y Panahi, AM Gorabi, S Talaei, F Beiraghdar… - Virology Journal, 2023 - Springer
Background The coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …
Fluorine-a small magic bullet atom in the drug development: perspective to FDA approved and COVID-19 recommended drugs
During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …
tool to get a biologically active compound. This belief can be supported by the fact that every …
Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)
S Juul, EE Nielsen, J Feinberg, F Siddiqui… - PLoS …, 2020 - journals.plos.org
Background Coronavirus disease 2019 (COVID-19) is a rapidly spreading disease that has
caused extensive burden to individuals, families, countries, and the world. Effective …
caused extensive burden to individuals, families, countries, and the world. Effective …
Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir
S Jockusch, C Tao, X Li, M Chien, S Kumar… - Scientific reports, 2020 - nature.com
SARS-CoV-2 is responsible for COVID-19, resulting in the largest pandemic in over a
hundred years. After examining the molecular structures and activities of hepatitis C viral …
hundred years. After examining the molecular structures and activities of hepatitis C viral …
Nucleoside analogs and nucleoside precursors as drugs in the fight against SARS-CoV-2 and other coronaviruses
Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family
Coronaviridae, that cause infections in a broad range of mammals including humans …
Coronaviridae, that cause infections in a broad range of mammals including humans …
Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture
X Wang, CQ Sacramento, S Jockusch… - Communications …, 2022 - nature.com
SARS-CoV-2 has an exonuclease-based proofreader, which removes nucleotide inhibitors
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …
such as Remdesivir that are incorporated into the viral RNA during replication, reducing the …