Atremorine in Parkinson's disease: From dopaminergic neuroprotection to pharmacogenomics

R Cacabelos, I Carrera, O Martínez… - Medicinal Research …, 2021 - Wiley Online Library
Atremorine is a novel bioproduct obtained by nondenaturing biotechnological processes
from a genetic species of Vicia faba. Atremorine is a potent dopamine (DA) enhancer with …

Targeting the RUNX3–miR-186-3p–DAT–IGF1R axis as a therapeutic strategy in a Parkinson's disease model

P Huang, Z Wan, S Qu - Journal of Translational Medicine, 2024 - Springer
With the increasing age of the population worldwide, the incidence rate of Parkinson's
disease (PD) is increasing annually. Currently, the treatment strategy for PD only improves …

Colorectal cancer early detection in stool samples tracing CpG islands methylation alterations affecting gene expression

AF Vega-Benedetti, E Loi, L Moi, S Orrù… - International Journal of …, 2020 - mdpi.com
Colorectal cancer (CRC) is a major cause of cancer mortality. Early diagnosis is relevant for
its prevention and treatment. Since DNA methylation alterations are early events in …

[HTML][HTML] Scoulerine: A natural isoquinoline alkaloid targeting SLC6A3 to treat RCC

T Qu, Y Sun, J Zhao, N Liu, J Yang, D Lyu… - Biomedicine & …, 2024 - Elsevier
Scoulerine, an isoquinoline alkaloid derived from the corydalis plant, exhibits diverse
therapeutic properties against tumors, Alzheimer's disease, and inflammation. This research …

[HTML][HTML] Weighted gene coexpression network analysis uncovers critical genes and pathways for multiple brain regions in parkinson's disease

J Huang, L Liu, L Qin, H Huang… - BioMed Research …, 2021 - pmc.ncbi.nlm.nih.gov
Objective In this study, we aimed to identify critical genes and pathways for multiple brain
regions in Parkinson's disease (PD) by weighted gene coexpression network analysis …

SLC6A3 as a potential circulating biomarker for gastric cancer detection and progression monitoring

S Liu, M Cui, J Zang, J Wang, X Shi, F Qian… - … -Research and Practice, 2021 - Elsevier
Background Gastric cancer is a malignant tumor originating from the gastric mucosal
epithelium, with no obvious symptoms at the early stage. The dopamine transporter gene …

The effect of aging, Parkinson's disease, and exogenous dopamine on the neural response associated with auditory regularity processing

A Al Jaja, JA Grahn, B Herrmann, PA MacDonald - Neurobiology of aging, 2020 - Elsevier
Processing regular patterns in auditory scenes is important for navigating complex
environments. Electroencephalography studies find enhancement of sustained brain activity …

[HTML][HTML] Dorsal striatum does not mediate feedback-based, stimulus-response learning: an event-related fMRI study in patients with Parkinson's disease tested on and …

NM Hiebert, AM Owen, H Ganjavi, D Mendonça… - Neuroimage, 2019 - Elsevier
Learning associations between stimuli and responses is essential to everyday life. Dorsal
striatum (DS) has long been implicated in stimulus-response learning, though recent results …

Dopaminergic signaling in prefrontal cortex contributes to the antidepressant effect of electroacupuncture: An iTRAQ‐based proteomics analysis in a rat model of …

J Zhang, J Zhang, Z Zhang, Y Zheng… - The Anatomical …, 2021 - Wiley Online Library
Electroacupuncture (EA) is used as an adjunctive treatment for depression. This study was
conducted to evaluate the efficacy and mechanisms of EA in the depressive rat model …

Influence of dopamine, noradrenaline, and serotonin transporters on the pharmacogenetics of Atremorine in Parkinson's disease

R Cacabelos, I Carrera, O Martínez… - Drug Development …, 2021 - Wiley Online Library
Atremorine is a potent dopamine (DA) enhancer obtained by nondenaturing
biotechnological processes from a genetic species of Vicia faba. Atremorine affects the …