Recent technological advancements have enabled the profiling of a large number of
genome-wide features in individual cells. However, single-cell data present unique …

Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Technology development in biological research often aims to either increase the number of
cellular features that can be surveyed simultaneously or enhance the resolution at which …

Subpopulation identification, usually via some form of unsupervised clustering, is a
fundamental step in the analysis of many single-cell RNA-seq data sets. This has motivated …

The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate
that these adaptations are precisely timed, reflecting an immune clock of pregnancy in …

The number of markers measured in both flow and mass cytometry keeps increasing
steadily. Although this provides a wealth of information, it becomes infeasible to analyze …

High-dimensional mass and flow cytometry (HDCyto) experiments have become a method
of choice for high-throughput interrogation and characterization of cell populations. Here, we …

Acute myeloid leukemia (AML) manifests as phenotypically and functionally diverse cells,
often within the same patient. Intratumor phenotypic and functional heterogeneity have been …