Recent advances in DNA gyrase-targeted antimicrobial agents
Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …
United States alone, it is responsible for the death of more than 20,000 people each year …
Recent progress in the discovery and development of DNA gyrase B inhibitors
New antibacterials that modulate less explored targets are needed to fight the emerging
bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search …
bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search …
[HTML][HTML] Synthesis and biological evaluation of 1, 2, 3-triazole tethered thymol-1, 3, 4-oxadiazole derivatives as anticancer and antimicrobial agents
ASA Almalki, S Nazreen, AM Malebari, NM Ali… - Pharmaceuticals, 2021 - mdpi.com
A library of 1, 2, 3-triazole-incorporated thymol-1, 3, 4-oxadiazole derivatives (6–18)
hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8 …
hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8 …
Design, synthesis, and antibacterial evaluation of new quinoline-1, 3, 4-oxadiazole and quinoline-1, 2, 4-triazole hybrids as potential inhibitors of DNA gyrase and …
HA Hofny, MFA Mohamed, HAM Gomaa… - Bioorganic …, 2021 - Elsevier
DNA gyrase and topoisomerase IV (topo IV) inhibitors are among the most interesting
antibacterial drug classes without antibacterial pipeline representative. Twenty-four new …
antibacterial drug classes without antibacterial pipeline representative. Twenty-four new …
New dual inhibitors of bacterial topoisomerases with broad-spectrum antibacterial activity and in vivo efficacy against vancomycin-intermediate Staphylococcus …
A new series of dual low nanomolar benzothiazole inhibitors of bacterial DNA gyrase and
topoisomerase IV were developed. The resulting compounds show excellent broad …
topoisomerase IV were developed. The resulting compounds show excellent broad …
[HTML][HTML] Induction of Antibacterial Metabolites by Co-Cultivation of Two Red-Sea-Sponge-Associated Actinomycetes Micromonospora sp. UR56 and Actinokinespora …
M S. Hifnawy, HM Hassan, R Mohammed, M M. Fouda… - Marine Drugs, 2020 - mdpi.com
Liquid chromatography coupled with high resolution mass spectrometry (LC-HRESMS)-
assisted metabolomic profiling of two sponge-associated actinomycetes, Micromonospora …
assisted metabolomic profiling of two sponge-associated actinomycetes, Micromonospora …
[HTML][HTML] Flavonoid-coated gold nanoparticles as efficient antibiotics against gram-negative bacteria—evidence from in silico-supported in vitro studies
Flavonoids are a class of bioactive plant-derived natural products that exhibit a broad range
of biological activities, including antibacterial ones. Their inhibitory activity toward Gram …
of biological activities, including antibacterial ones. Their inhibitory activity toward Gram …
Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies
A series of coumarin derivatives were designed, synthesized, and evaluated for their
antiproliferative activity. Compound 3e exhibited significant antiproliferative activity and was …
antiproliferative activity. Compound 3e exhibited significant antiproliferative activity and was …
Novel 1, 2, 4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study
TS Ibrahim, AJ Almalki, AH Moustafa, RM Allam… - Bioorganic …, 2021 - Elsevier
New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant
bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …
bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs …
[HTML][HTML] Design, synthesis, and antibacterial screening of some novel heteroaryl-based ciprofloxacin derivatives as DNA gyrase and topoisomerase IV inhibitors
A novel series of ciprofloxacin hybrids comprising various heterocycle derivatives has been
synthesized and structurally elucidated using 1H NMR, 13C NMR, and elementary analyses …
synthesized and structurally elucidated using 1H NMR, 13C NMR, and elementary analyses …