A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …

The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (≫
300kb) of DNA that are homogeneous in base composition and are compositionally …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

The sequence of the mouse genome is a key informational tool for understanding the
contents of the human genome and a key experimental tool for biomedical research. Here …

Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes
Down syndrome, the most frequent genetic cause of significant mental retardation, which …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

As whole-genome sequencing becomes commoditized and we begin to sequence and
analyze personal genomes for clinical and diagnostic purposes, it is necessary to …

В монографии изложены современные представления об этиологии и патогенезе
хромосомных болезней. Рассмотрены основные стадии гаметогенеза и эмбриогенеза …

The high degree of similarity between the mouse and human genomes is demonstrated
through analysis of the sequence of mouse chromosome 16 (Mmu 16), which was obtained …

The GC content of human DNA varies widely across the genome, ranging from 30% to 60%,
and regions of hundreds of kilobases (often referred to as isochores [Bernardi 2000]) may …