The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

The year 2021 marks the centennial of Banting and Best's landmark description of the
discovery of insulin. This discovery and insulin's rapid clinical deployment effectively …

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …

An open-label, first-in-human phase 1/2 study is being conducted to evaluate the safety and
efficacy of pancreatic endoderm cells (PECs) implanted in non-immunoprotective …

Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex
systems. However, a comprehensive single-cell atlas has not been achieved for humans …

Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but
there remain challenges towards achieving this goal,,,,–. Here we generate human islet-like …

Genetic engineering of allogeneic cell therapeutics that fully prevents rejection by a
recipient's immune system would abolish the requirement for immunosuppressive drugs or …

In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this
insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding …

We detail a six-stage planar differentiation methodology for generating human pluripotent
stem cell–derived pancreatic β cells (SC-β cells) that secrete high amounts of insulin in …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …