[HTML][HTML] Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease
J Brinks, EHC Van Dijk, I Klaassen… - Progress in retinal and …, 2022 - Elsevier
The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of
chorioretinal diseases, many of which are poorly understood. Recent advances in the field of …
chorioretinal diseases, many of which are poorly understood. Recent advances in the field of …
The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective
P Mammadzada, PM Corredoira, H André - Cellular and Molecular Life …, 2020 - Springer
Understanding the mechanisms that underlie age-related macular degeneration (AMD) has
led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have …
led to the identification of key molecules. Hypoxia-inducible transcription factors (HIFs) have …
[HTML][HTML] Primary endothelial cell–specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia
R Bartoszewski, A Moszyńska, M Serocki… - The FASEB …, 2019 - ncbi.nlm.nih.gov
During hypoxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …
1 and HIF-2) that respond to low tissue-oxygen levels and induce the expression of a …
Identification of the relationship between hub genes and immune cell infiltration in vascular endothelial cells of proliferative diabetic retinopathy using bioinformatics …
J Huang, Q Zhou - Disease Markers, 2022 - Wiley Online Library
Background. Diabetic retinopathy (DR) is a serious ophthalmopathy that causes blindness,
especially in the proliferative stage. However, the pathogenesis of its effect on endothelial …
especially in the proliferative stage. However, the pathogenesis of its effect on endothelial …
Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway
K Zhao, Y Jiang, J Zhang, J Shi, P Zheng, C Yang… - Cell Cycle, 2022 - Taylor & Francis
Retinopathy of prematurity (ROP), which is characterized by retinal neovascularization
(RNV), is a major cause of neonatal blindness. The primary treatment for ROP is anti …
(RNV), is a major cause of neonatal blindness. The primary treatment for ROP is anti …
Anti-inflammatory and anti-oxidative synergistic effect of vitamin D and nutritional complex on retinal pigment epithelial and endothelial cell lines against age-related …
Age-related macular degeneration (AMD) is a multifactorial disease of the retina featured by
dysfunction of retinal pigmented epithelial (RPE) and loss of photoreceptor cells under …
dysfunction of retinal pigmented epithelial (RPE) and loss of photoreceptor cells under …
MicroRNAs and the HIF/VEGF axis in ocular neovascular diseases
Ocular neovascular diseases, such as proliferative diabetic retinopathy, retinopathy of
prematurity and neovascular age‐related macular degeneration, are the leading causes of …
prematurity and neovascular age‐related macular degeneration, are the leading causes of …
Effects of an aquaporin 4 inhibitor, TGN-020, on murine diabetic retina
S Oosuka, T Kida, H Oku, T Horie, S Morishita… - International Journal of …, 2020 - mdpi.com
Purpose: To investigate the effect of a selective aquaporin 4 (AQP4) inhibitor, 2-
(nicotinamide)-1, 3, 4-thiadiazole (TGN-020), on the expression of vascular endothelial …
(nicotinamide)-1, 3, 4-thiadiazole (TGN-020), on the expression of vascular endothelial …
Long non‐coding RNA OIP5‐AS1 (Cyrano): a context‐specific regulator of normal and disease processes
S Wooten, KN Smith - Clinical and Translational Medicine, 2022 - Wiley Online Library
Long non‐coding (lnc) RNAs have been implicated in a plethora of normal biological
functions, and have also emerged as key molecules in various disease processes. OIP5 …
functions, and have also emerged as key molecules in various disease processes. OIP5 …
Discovery of the signal pathways and major bioactive compounds responsible for the anti-hypoxia effect of Chinese cordyceps
H Long, X Qiu, L Cao, R Han - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Hypoxia will cause an increase in the rate of fatigue and
aging. Chinese cordyceps, a parasitic Thitarodes insect-Ophiocordyceps sinensis fungus …
aging. Chinese cordyceps, a parasitic Thitarodes insect-Ophiocordyceps sinensis fungus …