Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

The brain is a highly adaptable organ that is capable of converting sensory information into
changes in neuronal function. This plasticity allows behavior to be accommodated to the …

The transcription factor SRF (serum response factor) recruits two families of coactivators, the
MRTFs (myocardin-related transcription factors) and the TCFs (ternary complex factors), to …

X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder.
During the past two decades in excess of 100 X-chromosome ID genes have been …

Fibroblasts differentiate into myofibroblasts by acquiring new contractile function. This is
important for tissue repair, but it also contributes to organ fibrosis. Platelet-derived growth …

Although many details remain still elusive, it became increasingly evident in recent years
that mechanosensing of microenvironmental biophysical cues and subsequent …

Autism spectrum disorders (ASD) are neurodevelopmental disorders with phenotypic and
genetic heterogeneity. Recent studies have reported rare and de novo mutations in ASD, but …

The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac
regenerative medicine. In development, cardiomyocyte maturation is characterized by …

Cardiac fibroblasts are responsible for necrotic tissue replacement and scar formation after
myocardial infarction (MI) and contribute to remodeling in response to pathological stimuli …

Actin-based cell migration is a fundamental cellular activity that plays a crucial role in a wide
range of physiological and pathological processes. An essential feature of the remodeling of …