Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Cardiovascular disease is the leading cause of morbidity and mortality in diabetes. Recent
clinical studies indicate that sodium-glucose co-transporter 2 (SGLT2) inhibitors improve …

Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …

Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen
species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in …

Cardiologists and most physicians believe that aging is an independent risk factor for human
atherosclerosis, whereas atherosclerosis is thought to be a characteristic feature of aging in …

Age is an independent risk factor of cardiovascular disease, even in the absence of other
traditional factors. Emerging evidence in experimental animal and human models has …

Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired
angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of …