Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and
subsequent gamete fertilization in mosquitoes is essential for the spreading of the disease …

Plasmodium sporozoites are deposited in the host skin by Anopheles mosquitoes. The
parasites migrate from the dermis to the liver, where they invade hepatocytes through a …

Malaria parasites replicate within a parasitophorous vacuole in red blood cells (RBCs).
Progeny merozoites egress upon rupture of first the parasitophorous vacuole membrane …

One of the hallmarks of the parasitic phylum of Apicomplexa is the presence of highly
specialised, apical secretory organelles, called the micronemes and rhoptries that play …

In the asexual blood stages of malarial infection, merozoites invade erythrocytes and
replicate within a parasitophorous vacuole to form daughter cells that eventually exit …

Human malaria, caused by infection with Plasmodium parasites, remains one of the most
important global public health problems, with the World Health Organization reporting more …

Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to
barrier penetration, tissue dissemination, inflammation, and pathogen transmission. Like cell …

The coordinated exit of intracellular pathogens from host cells is a process critical to the
success and spread of an infection. While phospholipases have been shown to play …