The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of
vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion …

Secretory proteins are transported from the endoplasmic reticulum (ER) to the Golgi complex
in carriers that are formed by the concerted activities of cytoplasmic proteins in the coat …

Tendons and ligaments are fibrous connective tissues vital to the transmission of force and
stabilization of the musculoskeletal system. Arising in precise regions of the embryo …

Exit of secretory cargo from the endoplasmic reticulum (ER) takes place at specialized
domains called ER exit sites (ERESs). In mammals, loss of TANGO1 and other MIA/cTAGE …

Myogenesis is a highly orchestrated, complex developmental process by which cell lineages
that are mesodermal in origin generate differentiated multinucleate muscle cells as a final …

Collagen IV networks endow basement membranes (BMs) with remarkable tensile strength
and function as morphoregulatory substrata for diverse tissue-specific developmental …

Secretory cargos are collected at endoplasmic reticulum (ER) exit sites (ERES) before
transport to the Golgi apparatus. Decades of research have provided many details of the …

TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that
cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of …

Derangements in tendon matrisome are pathognomonic for musculoskeletal disorders
including rotator cuff tendinopathies (RCT). Collagen type-1 accounts for more than 85% of …

Tango1 enables ER-to-Golgi trafficking of large proteins. We show here that loss of Tango1,
in addition to disrupting protein secretion and ER/Golgi morphology, causes ER stress and …