Histone modifications are the key epigenetic mechanisms that have been identified to
regulate gene expression in many human diseases. However, in the early developmental …

Highlights•Computational drug repositioning is a serious support tool to shortlist candidate
drugs.•Up-to-date review of drug repositioning methodologies.•Example of a drug …

Background: Ruminant species are at risk of developing abomasal ulceration, but there is a
lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor …

Background Stressed and hospitalized goats are at risk of developing abomasal (gastric)
ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs …

Clinical safety data for the use of gastroprotectants in hospitalized ruminants is lacking. In
human patients, multiple adverse effects are possible from the use of pantoprazole including …

An epigenetic effect mainly refers to a heritable modulation in gene expression in the short
term but does not involve alterations in the DNA itself. Epigenetic molecular mechanisms …

Precision medicine pivots on the integration of patients' individual data including genetic
and genomic data, digital health measures, and social health factors, for the prevention …

With the demand for more efficient and safer therapeutic drugs, targeted therapeutic
peptides are well received due to their advantages of high targeting (specificity), low …

Infectious respiratory diseases are a serious health concern worldwide. However, few
models describe the experimental induction of lung infection, or the effect of experimental …

The personalized medicine movement pivots on the integration of patients' genetic and
genomic data for prevention, diagnosis, and treatment. However, it does not refer to a single …