Publisher Summary This chapter highlights endosymbiont hypothesis. All contemporary
genomes (including those of plastids and mitochondria) ultimately derive from a single …

The concept proposed by Woese and associates in the late 1970s reclassified all living
organisms into three primary kingdoms: eucaryotes, eubacteria, and archaebacteria (127 …

The biosynthesis of methane is limited to a rather specialized group of bacteria, the
methanogens, that live in waterlogged soils, guts of animals, sewage sludge, manure piles …

In the last 10 years, considerable information has accumulated on the biochemistry of
archaea. In this volume, the subject as a whole is treated in a comprehensive manner. The …

Eukaryotic and archaeal elongation factor 2 contains a unique post-translationally modified
histidine residue, named diphthamide. Genetic and biochemical studies have revealed that …

Diphthamide, the target of diphtheria toxin, is a unique posttranslational modification on
translation elongation factor 2 (EF2) in archaea and eukaryotes. The biosynthesis of …

A mutant of Saccharomyces cerevisiae defective in the S-adenosylmethionine (AdoMet)-
dependent methyltransferase step of diphthamide biosynthesis was selected by intracellular …

The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the
translation elongation factor, eEF2 (also known as EFT1). This enigmatic modification occurs …

We developed a selection procedure based on the observation that diphtheria toxin kills
spheroplasts of Saccharomyces cerevisiae (Murakami et al., Mol. Cell. Biol. 2: 588–592 …

The elongation factor 2 (EF-2) genes of the yeast Saccharomyces cerevisiae have been
cloned and characterized with the ultimate goal of gaining a better understanding of the …