DprE1 and Ddn as promising therapeutic targets in the development of novel anti-tuberculosis nitroaromatic drugs

R Paoli-Lombardo, N Primas, P Vanelle - European Journal of Medicinal …, 2024 - Elsevier
Tuberculosis remains the second deadliest infectious disease in humans and a public
health threat due to the emergence of multidrug-resistant (MDR-TB) and extensively drug …

Functions of nitroreductases in mycobacterial physiology and drug susceptibility

IE Eke, RB Abramovitch - Journal of Bacteriology, 2025 - journals.asm.org
Tuberculosis is a respiratory infection that is caused by members of the Mycobacterium
tuberculosis complex, with M. tuberculosis (Mtb) being the predominant cause of the disease …

Unveiling the Antitubercular Potential of Furan–Nitrophenyl Schiff Base Hybrids: A Molecular Docking and Drug-Likeness Perspective

GA Abdelwahab, MR Elmorsy, AA Fadda… - Russian Journal of …, 2024 - Springer
In this study, we report the synthesis and characterization using various spectroscopic
techniques of a series of six new furan-based Schiff base derivatives as potential …

Chemical Genetics of New Nitro-Containing Compounds That Inhibit the Growth of Mycobacterium tuberculosis and M. abscessus

IE Eke - 2024 - search.proquest.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a respiratory infection
with a global distribution. TB chemotherapy is faced with many challenges, including the …