Cognition can be conceptualized as a set of algorithmic control functions whose real-time
deployment determines how an organism stores and uses information to guide thought and …

Cortical gain regulation allows neurons to respond adaptively to changing inputs. Neural
gain is modulated by internal and external influences, including attentional and arousal …

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

The spiking neural network (SNN) is regarded as a promising candidate to deal with the
great challenges presented by current machine learning techniques, including the high …

Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

In the nervous system, dendrites, branches of neurons that transmit signals between
synapses and soma, play a critical role in processing functions, such as nonlinear …

Cortical neurons exhibit extreme diversity in gene expression as well as in morphological
and electrophysiological properties 1, 2. Most existing neural taxonomies are based on …

Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …

The mystery of general anesthesia is that it specifically suppresses consciousness by
disrupting feedback signaling in the brain, even when feedforward signaling and basic …