Cell cycle checkpoints activated by DNA double-strand breaks (DSBs) are essential for the
maintenance of the genomic integrity of proliferating cells. Following DNA damage, cells …

Regulatory circuits controlling gene expression constantly rewire to adapt to environmental
stimuli, differentiation cues, and disease. We review our current understanding of the …

Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21 …

Cell-cycle arrest, apoptosis, and senescence are widely accepted as the major mechanisms
by which p53 inhibits tumor formation. Nevertheless, it remains unclear whether they are the …

Many chemotherapeutic drugs kill only a fraction of cancer cells, limiting their efficacy. We
used live-cell imaging to investigate the role of p53 dynamics in fractional killing of colon …

Cells transmit information through molecular signals that often show complex dynamical
patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the …

It is not understood why healthy tissues can exhibit varying levels of sensitivity to the same
toxic stimuli. Using BH3 profiling, we find that mitochondria of many adult somatic tissues …

Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but
mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA …

Many biological networks respond to various inputs through a common signaling molecule
that triggers distinct cellular outcomes. One potential mechanism for achieving specific input …

Abstract Information about environmental stimuli is often transmitted using common
signaling molecules, but the mechanisms that ensure signaling specificity are not entirely …